Microprojection array immunization patch and method

Details Microprojection array immunization patch and method Microprojection array immunization patch and method

A - Human Necessities

61

B

A61B 17/20 (2006.01)

Patent

CA 2530954

Microprojection members (10) having a reservoir containing an antigenic agent and methods of using such members to vaccinate mammals (e.g., humans) are disclosed. The microprojection members are used to transdermally deliver an antigenic agent (e.g., a vaccine antigen) with substantially reduced skin reactions. This is achieved by delivering an induction amount and thereafter delivering one or more subsequent booster amounts. The induction amount is relatively larger than the booster amount. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy and convenience of use.

L'invention concerne des éléments à microprojections (10) pourvus d'un réservoir contenant un agent antigénique. L'invention concerne également des méthodes d'utilisation associées de vaccination de mammifères (d'humains, par exemple). Ces éléments à microprojections sont utilisés dans l'administration transdermique d'un agent antigénique (d'un antigène de vaccin, par exemple) dont les réactions cutanées sont sensiblement réduites. On administre d'abord une dose d'induction, puis au moins une dose de rappel. La dose d'induction est relativement plus importante que la dose de rappel. Cette technique peut être appliquée largement, pour une grande variété de vaccins thérapeutiques afin d'améliorer leur efficacité et leur facilité d'utilisation.

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