Microrna compositions and methods for the treatment of...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/7105 (2006.01) A61K 35/14 (2006.01) A61P 35/02 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2733676

The invention provides methods, uses, kits and compositions comprising a therapeutically effective amount of the microRNA miR-223 for treating myelogenous leukemia in a subject in need of such treatment. The invention further comprises methods encompassing the use of miR-223 for promoting the differentiation of a leukemia stem cell that is resistant to a differentiating agent, and a method of screening for candidate compounds capable of treating a myeloid leukemia by comparison of the therapeutic activity of the candidate compound with the therapeutic activity of miR-233.

La présente invention concerne des procédés, des utilisations, des ensembles et des compositions contenant une quantité thérapeutiquement efficace du micro-ARN miR-223 pour traiter la leucémie myélogène chez un sujet nécessitant ledit traitement. L'invention comprend, en outre, des procédés utilisant miR-223 pour promouvoir la différenciation d'une cellule-souche leucémique qui résiste à un agent de différenciation, et un procédé de criblage permettant de sélectionner des composés candidats capables de traiter une leucémie myéloïde, ledit procédé comparant l'activité thérapeutique du composé candidat à l'activité thérapeutique de miR-233.

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