Microrna-mediated regulation of ubc9 expression in cancer cells

A - Human Necessities – 61 – K

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A61K 31/7088 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2742991

Novel small expressed microRNA molecules associated with physiological regulatory mechanisms and particularly in developmental control are provided herein. More particularly, the present invention relates to microRNA molecules that suppress cancerous cell growth and other cancer-related disorders by suppressing tumor promoting factors such as, for example, Ubc9. Further, it is contemplated that the use of the microRNA molecules hereof will improve the diagnoses, prevention and/or treatment and also the identification and development of pharmaceuticals that are effective in connection with cancer cell growth.

La présente invention concerne de nouvelles molécules de micro-ARN exprimées, de petite taille, associées à des mécanismes de régulation physiologiques et, en particulier, au contrôle du développement. Plus particulièrement, la présente invention concerne des molécules de micro-ARN qui suppriment la croissance des cellules cancéreuses et autres troubles liés au cancer par suppression des facteurs favorisant les tumeurs tels que, par exemple, Ubc9. Linvention décrit, en outre, que l'utilisation desdites molécules de micro-ARN devrait améliorer les diagnostics, la prévention et/ou le traitement, ainsi que l'identification et la mise au point de produits pharmaceutiques efficaces dans le domaine de la croissance des cellules cancéreuses.

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