Microsomal triglyceride transfer protein inhibitors

Details Microsomal triglyceride transfer protein inhibitors Microsomal triglyceride transfer protein inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) C07C 237/52 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2510815

The present invention provides inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion having Formula (I) which are useful for the treatment of obesity and related diseases, as well as prevention and treatment of atherosclerosis and its clinical sequelae, for lowering serum lipids, and in the prevention and treatment of related diseases. The invention further relates to pharmaceutical compositions comprising the compounds of the present invention and to methods of treating obesity, atherosclerosis, and related diseases and/or conditions with the compounds of the present invention, either alone or in combination with other pharmaceutical agents, including lipid-lowering agents.

La présente invention concerne des inhibiteurs de protéine de transfert de triglycéride microsomale (MTP) et/ou de sécrétion d'apolipoprotéine B (Apo B) représentés par la formule (I), qui conviennent pour le traitement de l'obésité et des maladies associées, ainsi que pour la prévention et le traitement de l'athérosclérose et de ses séquelles cliniques, pour abaisser les lipides sériques et, pour la prévention et le traitement de maladies associées. Cette invention concerne aussi des compositions pharmaceutiques comprenant les composés de l'invention et des techniques de traitement de l'obésité, de l'athérosclérose et des maladies et états associés, avec les composés de cette invention, soit seuls, soit en combinaison avec d'autres agents pharmaceutiques, notamment des agents hypolipidémiants.

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