A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) A61K 38/28 (2006.01)
Patent
CA 2657517
AS-oIigonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to reverse an autoimmune diabetes condition in NOD mice in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
La présente invention concerne des oligonucléotides antisens qui sont libérés sous forme de microsphères afin d'induire une tolérance des cellules dendritiques, particulièrement dans le modèle de souris diabétiques non obèses. Les microsphères incorporent des oligonucléotides antisens (AS). Le procédé selon l'invention consiste à utiliser une approche antisens pour renverser un état diabétique auto-immun chez des souris diabétiques non obèses in vivo. Les oligonucléotides sont ciblés pour se lier à des produits de transcription primaires CD40, CD80, CD86 et leurs combinaisons.
Brown Larry R.
Giannoukakis Nick
Gillis Kimberly A.
Baxter Healthcare S.a.
Baxter International Inc.
Sim & Mcburney
University Of Pittsburgh - Of The Commonwealth System Of Higher
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