A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 47/48 (2006.01) A61L 2/18 (2006.01) B01J 13/02 (2006.01)
Patent
CA 2178620
A sustained release drug delivery composition and a method of making same are provided which comprises microspheres containing a pharmaceutically active agent, a core of an ion-exchange resin and a polymeric coating completely surrounding the core wherein the coating is water-insoluble and hydrolytically stable in physiological environments. The coating is non-erodible in physiological environments and is characterized by a diffusion constant suitable for the pharmaceutical agent to diffuse from the core to an aqueous environment at a predetermined release rate.
L'invention concerne une composition de libération de médicament prolongée et son procédé de fabrication. Ladite composition comprend des microbilles contenant un principe actif, un noyau en résine échangeuse d'ions entièrement entouré d'un enrobage polymère insoluble dans l'eau et stable du point de vue hydrolytique dans des environnements physiologiques. Ledit enrobage ne s'érode pas dans des environnements physiologiques et permet une diffusion constante de l'agent pharmaceutique depuis le noyau dans un environnement aqueux à un taux de libération prédéterminé.
Jungherr Lisa B.
Ottoboni Thomas B.
Smart & Biggar
Vitaphore Corporation
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