Microspheres having core/shell structure

Details Microspheres having core/shell structure Microspheres having core/shell structure

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2691597

Disclosed are microspheres having a core/shell structure and a spherical shape, wherein (a) the core comprises solid-state aripiprazole, and (b) the shell coats all or most of the surface of the core, and the shell comprises a biodegradable polymer; a process for producing the microspheres; and an injectable aqueous suspension formulation containing the microspheres; and the like.

La présente invention concerne des microsphères ayant une structure noyau/enveloppe et une forme sphérique, dans lesquelles (a) le noyau comporte de l'aripiprazole à l'état solide, et (b) l'enveloppe enrobe la totalité ou la majorité de la surface du noyau, et l'enveloppe comporte un polymère biodégradable. L'invention concerne également un procédé de production des microsphères ainsi qu'une formulation en suspension aqueuse injectable contenant les microsphères, et analogues.

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