Microtiter plate format device and methods for separating...

G - Physics – 01 – N

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Details

G01N 27/26 (2006.01) C12Q 1/37 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) G01N 27/447 (2006.01) G01N 33/561 (2006.01)

Patent

CA 2428568

A system for separating molecules comprising: a plurality of tubular sample wells arrayed in a sample plate; at least one capture matrix disposed in each of the sample wells proximate the bottom of the sample well; at least one electrical contact with the bottom end of each sample well, and at least one second electrode in electrical contact with the top end of each sample well.

La présente invention concerne, de manière générale, des dispositifs de type plaques de microtitrage, et des procédés permettant de séparer des molécules présentant des charges nettes différentes. Les dispositifs et les procédés décrits dans cette invention conviennent tout particulièrement au criblage haut rendement afin de contrôler les réactions enzymatiques donnant naissance à un produit présentant une charge nette modifiée. Par exemple, les systèmes et les procédés décrits dans cette invention peuvent être utilisés pour détecter l'activité des phosphatases, des protéases et des kinases sur divers substrats peptidiques dans diverses conditions.

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