Microwave dielectric spectroscopy method and apparatus for...

G - Physics – 01 – N

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G01N 22/00 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2462341

Dielectric spectroscopy is carried out by coupling non~radiated microwave energy from an antenna to a sample to detect changes in the permittivity of the sample within the antenna's near field. The frequency response of the antenna exhibits resonant frequencies in a frequency range of interest. Changes in the sample as a result of changes in environmental conditions of the sample are exhibited as changes in the antenna's resonant frequency or frequencies. The changes in the positions of the peaks with changes in environmental conditions can be correlated to changes in the condition of the sample, such as unfolding of proteins with increases in temperature of the sample.

On effectue une spectroscopie diélectrique en couplant une énergie non rayonnante d'une antenne à un échantillon afin de détecter les modifications du facteur de permittivité de l'échantillon dans le champ proche de l'antenne. La réponse de fréquence de l'antenne présente des fréquences résonantes dans une plage de fréquences d'intérêt. Les modifications de l'échantillon découlant des modifications des conditions environnementales de l'échantillon se présentent sous forme de modifications dans la ou les fréquences résonantes de l'antenne. Les modifications de position des crêtes associées aux modifications des conditions environnementales peuvent être mises en corrélation avec les modifications de l'état de l'échantillon tel que le non repliement des protéines associé à une augmentation de température de l'échantillon.

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