C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/5025 (2006.01) A61K 31/519 (2006.01) A61P 1/00 (2006.01) A61P 21/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2718558
The present invention relates to substituted imidazopyrimidine derivatives, substituted imidazopyrazine derivatives and substituted imidazopyridazine derivatives as melanocortin-4 receptor (MC- 4R) modulators, in particular as melanocortin 4 receptor antagonists. The antagonists are useful for the treatment of disorders and diseases such as cachexia induced by e.g. cancer, chronic kidney disease (CKD) or chronic heart failure (CHF), muscle wasting, anorexia induced by e.g. chemotherapy or radiotherapy, anorexia nervosa, amyotrophic lateral sclerosis (ALS), pain, neuropathic pain, anxiety and depression, nausea and emesis. Formula (I).
La présente invention concerne des dérivés d'imidazopyrimidine substitués, des dérivés d'imidazopyrazine substitués, et des dérivés d'imidazopyridazine substitués qui conviennent comme modulateurs du récepteur de la mélanocortine-4 (MC-4R), en particulier comme antagonistes du récepteur de la mélanocortine-4. Ces antagonistes conviennent pour le traitement de troubles et d'affections tels que l'émaciation induite notamment par le cancer, la néphrite chronique, l'insuffisance cardiaque chronique, l'amyotrophie, l'anorexie induite notamment par la chimiothérapie ou la radiothérapie, l'anorexie mentale, la sclérose amyotrophique latérale, la douleur, la douleur neuropathique, l'anxiété et la dépression, les nausées et les vomissements.
Abel Ulrich
Deppe Holger
Feurer Achim
Hoffmann-Enger Barbara
Metz Gunther
Robic
Santhera Pharmaceuticals (schweiz) Ag
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