Migrastatin analogs and uses thereof

Details Migrastatin analogs and uses thereof Migrastatin analogs and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 225/02 (2006.01) A61K 31/365 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01) C07C 13/02 (2006.01) C07D 313/00 (2006.01) C07D 405/06 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2520732

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1-R6, Ra- Rc, Q, Yl, Y2 and n are as defined herein.

La présente invention concerne des composés de formule I, et des procédés de leur synthèse, leurs compositions et des procédés d'utilisation desdits composés dans le traitement de différents troubles, y compris le cancer, la métastase et des troubles impliquant l'angiogénèse accrue, dans laquelle R¿1?-R¿6?, R¿a?-R¿c?, Q, Y¿l?, Y¿2? et n sont tels que définis dans le descriptif.

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