Mild osteoarthritis biomarkers and uses thereof

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/10 (2006.01) C12P 19/34 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01) C40B 40/10 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2599589

The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.

L'invention concerne l'identification et la sélection de combinaisons de biomarqueurs qui sont exprimés de manière différentielle chez des individus selon qu'ils sont atteints ou non d'ostéoarthrite bénigne. Sont également décrits des polynucléotides et des protéines s'hybridant spécifiquement et/ou sélectivement avec les produits de biomarqueurs de l'invention ainsi que des kits renfermant lesdits polynucléotides et protéines utilisés pour le diagnostic de l'ostéoarthrite bénigne. L'invention porte en outre sur l'utilisation des polynucleotides et protéines s'hybridant spécifiquement et/ou sélectivement avec les produits de biomarqueurs de l'invention pour surveiller le recul de la maladie chez un individu et l'efficacité des traitements thérapeutiques. Enfin, l'invention concerne des méthodes d'utilisation des produits de biomarqueurs pour l'identification de nouvelles cibles thérapeutiques dans le cas de l'ostéoarthrite.

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