Milling process for the production of finely milled...

A - Human Necessities – 61 – K

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Details

A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 31/137 (2006.01) A61K 31/573 (2006.01) B02C 19/06 (2006.01) A61J 3/02 (2006.01)

Patent

CA 2352796

The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30 % and 70 %. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced.

L'invention concerne un procédé amélioré de production de poudres médicamenteuses très fines, conçues pour être inhalées. On utilise un broyeur à tuyère, avec des fluides de broyage classiques tels que de l'air ou de l'azote. On traite d'abord le fluide de broyage de manière que celui-ci possède une humidité relative régulée comprise entre 30 et 70 %, ce qui permet d'obtenir une poudre médicamenteuse très fine possédant une dimension particulaire moyenne inférieure à 10 micromètres et peu ou pas de contenu amorphe produit lors du broyage. De même, grâce à ce procédé, on diminue grandement la formation de tartre dans la chambre de broyage.

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