C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 7/06 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2234661
The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C- 34 mimotopes, are specifically provided.
La présente invention se rapporte à un peptide isolé qui simule un site de liaison d'un anticorps monoclonal, ce dernier reconnaissant un épitope dans le complexe de la glycoprotéine plaquettaire humaine Ib/IX. Ce peptide est appelé un mimotope. L'invention se rapporte également à une molécule isolée capable de se fixer au peptide ou au mimotope, cette molécule pouvant être un anticorps, un second peptide, un glucide ou autres molécules naturelles ou synthétisées chimiquement. Cette molécule isolée est appelée un anti-mimotope. L'invention se rapporte spécifiquement à des mimotopes simulant le site de liaison de l'anticorps monoclonal C-34 et SZ-2, ainsi qu'à des anti-mimotopes dirigés contre les mimotopes C-34.
Lyle Vicki A.
Miller Jonathan L.
Gowling Lafleur Henderson Llp
Rcbt Llc Series II
The Research Foundation Of State University Of New York
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