Minactivin

C - Chemistry – Metallurgy – 12 – N

Patent

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167/37, 150/5, 5

C12N 9/72 (2006.01) C07K 14/81 (2006.01) C07K 16/40 (2006.01) C12P 21/02 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341407

Minactivin, a protein inactivator of urokinase-type plasminogen activator, has been shown to be a natural inactivator of this plasminogen activator which is associated with invasive tumours, and is therefore indicated as a crucial element in the body's normal defense against tumour invasion and metastasis. It may be produced by the cultivation of minactivin-producing cells in vitro, and recovery of the cell culture supernatant. By controlling the culture conditions, the protein minactivin may be produced in a partially purified form which may be used for diagnosis and treatment of tumours.

488622

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