Mineralization and cellular patterning on biomaterial surfaces

Details Mineralization and cellular patterning on biomaterial surfaces Mineralization and cellular patterning on biomaterial surfaces

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61L 27/38 (2006.01) A61L 27/50 (2006.01)

Patent

CA 2370063

Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.

La présente invention concerne des procédés permettant de réaliser facilement sur des biomatériaux des minéralisations et des développements cellulaires superficiels. Ces procédés conviennent particulièrement à la génération de matériaux d'implants biologiques tridimensionnels ou en relief aux surfaces pourvues de développements cellulaires, éventuellement minéralisées. L'invention concerne également divers procédés permettant d'utiliser à des fins de génie tissulaire, notamment osseux, ces biomatériaux minéralisés et/ou pourvus de développements cellulaires. Ces procédés permettent une meilleure maîtrise du déroulement des processus biologiques (minéralisation, libération du facteur de croissance, fixation cellulaire et croissance tissulaire).

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