Mineralized collagen-polysaccharide matrix for bone and...

Details Mineralized collagen-polysaccharide matrix for bone and... Mineralized collagen-polysaccharide matrix for bone and...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 9/14 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/30 (2006.01) A61L 27/26 (2006.01)

Patent

CA 2427047

A matrix and a method for preparing it are provided to support the growth of tissue, such as bone, cartilage or soft connective tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent linkages to mineralized collagen. The matrix can be implanted or injected, or the polyaldehyde polysaccharide and mineralized collagen starting minerals can be separately injected to form the matrix in situ.

L'invention concerne une matrice et un procédé de préparation de celle-ci. Cette matrice sert de support à la croissance de tissus, tels que des os, du cartilage ou des tissus conjonctifs mous. On fait réagir un polysaccharide avec un agent oxydant afin d'ouvrir les cycles glucidiques sur le polysaccharide de façon à former des groupes aldéhyde. On fait ensuite réagir ces groupes aldéhyde de manière à former des liaisons covalentes avec le collagène minéralisé. La matrice de l'invention peut être implantée ou injetée, ou les matériaux minéraux de départ du polysaccharide polyaldéhyde et du collagène minéralisé peuvent être injectés séparément afin de former la matrice in situ.

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