Mini-proinsulin, its preparation and use

Details Mini-proinsulin, its preparation and use Mini-proinsulin, its preparation and use

C - Chemistry, Metallurgy

12

N

195/1.22, 195/1.

C12N 15/17 (2006.01) C07K 14/62 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341211

A mini-proinsulin, in which the amino acid Arg bridges the A and the B chain instead of the C chain, shows insulin activity and is suitable for the preparation of pharmaceuticals for the treatment of diabetes mellitus. It can furthermore be converted into an insulin derivative simply using trypsin, the B chain of which is lengthened by Arg. This can be converted into insulin using carboxypeptidase B. Advantageously, however, the mini-proinsulin can also be converted to insulin directly in a one-pot process.

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