C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) C12N 1/20 (2006.01) C12N 15/00 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2728291
The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site--specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.
La présente invention concerne des formulations de vecteurs dacides nucléiques minicercle destinées à être utilisées dans ladministration à un sujet. Les vecteurs dacides nucléiques minicercle comportent un polynucléotide dintérêt, et une séquence hybride de produits dune recombinase unidirectionnelle spécifique de site, et sont exempts de séquence dADN bactérienne de squelette. Linvention concerne également des procédés de production de formulations selon linvention ainsi que des procédés dadministration des formulations de vecteurs dacides nucléiques minicercle à un sujet. Les procédés et les compositions selon linvention peuvent être utilisés dans une variété dapplications différentes, comprenant des applications de recherche ainsi que des applications thérapeutiques.
Chen Zhi-Ying
Kay Mark A.
Fetherstonhaugh & Co.
The Board Of Trustees Of The Leland Stanford Junior University
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