Minigastrin as a therapeutic agent

Details Minigastrin as a therapeutic agent Minigastrin as a therapeutic agent

A - Human Necessities

61

K

A61K 38/10 (2006.01)

Patent

CA 2698822

The present invention is directed to the use of the peptide compound Leu-Glu- Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp- Met-Asp-Phe-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr- Gly-Trp-Met-Asp-Phe-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

L'invention concerne l'utilisation d'un composé peptidique Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 comme agent thérapeutique pour la prophylaxie et/ou le traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodégénératives, de maladies infectieuses, de maladies pulmonaires, de maladies cardiaques et vasculaires et de maladies métaboliques. L'invention concerne également des compositions pharmaceutiques, de préférence sous forme de lyophilisat ou de solution tampon liquide ou de formulation de lait maternel artificiel ou de substitut du lait maternel contenant le peptide Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 éventuellement avec au moins un véhicule, un cryoprotecteur, un lyoprotecteur, un excipient et/ou un diluant pharmaceutiquement acceptable.

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