Minimally compliant, volume efficient piston for osmotic...

A - Human Necessities – 61 – M

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A61M 31/00 (2006.01) A61K 9/00 (2006.01) A61M 5/145 (2006.01)

Patent

CA 2490544

An osmotic pump having a minimally compliant, volume efficient piston positioned within a capsule. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length to total diameter ratio of about 1.1:1 and a core diameter to total diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

L'invention concerne une pompe osmotique pourvue d'un piston peu flexible efficace d'un point de vue volumique positionné dans une capsule. La capsule comprend une surface intérieure, un agent utile et un agent osmotique. Le piston est amovible par rapport à une surface intérieure de la capsule, et définit un joint d'étanchéité amovible avec la surface intérieure de la capsule. Le joint d'étanchéité amovible sépare l'agent osmotique de l'agent utile. Le piston présente un rapport longueur/diamètre total d'environ 1.1:1 et un rapport diamètre central/diamètre total d'environ 0.9:1. Le piston permet d'obtenir une charge utile de l'agent utile et/ou de l'agent osmotique supérieure sans augmenter la dimension de la capsule. L'agent osmotique absorbe le liquide de l'environnement alentour à travers un corps semi-perméable pour faire bouger le piston et provoquer ainsi l'administration de l'agent utile de la capsule.

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