Minus strand rna viral vectors carrying a gene with altered...

Details Minus strand rna viral vectors carrying a gene with altered... Minus strand rna viral vectors carrying a gene with altered...

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) C12N 15/45 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2530627

It is intended to provide a minus strand RNA virus having a foreign gene in which a partial sequence in the E sequence of the minus strand RNA virus contained in its gene sequence has been modified. It is found out that a foreign gene containing a part of the E sequence suffers from a mutation at a high frequency in a minus strand RNA virus. Therefore, the occurrence of a mutation in the gene carried by the minus strand RNA virus can be prevented by modifying the sequence of the foreign gene so as to delete the above sequence.

L'objectif de l'invention est de fournir un virus à ARN à brin négatif porteur d'un gène étranger dans lequel une séquence partielle de la séquence E du virus à ARN à brin négatif contenue dans sa séquence de gène a été modifiée. Il s'avère qu'un gène étranger contenant une partie de la séquence E subit une mutation à haute fréquence dans un virus à ARN à brin négatif. Ainsi, l'apparition d'une mutation dans le gène porté par le virus à ARN à brin négatif peut être évitée par modification de la séquence du gène étranger de façon à supprimer la séquence susmentionnée.

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