Miotic agents and hypertonic agents containing ophthalmic...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2370895

Ophthalmic compositions able to reduce the impairments of the visual function (like halos, glare and reduction of the night and twilight vision) resulting from keratectomy operations carried out both with laser and by conventional techniques, from intraocular lens implantation (cataract surgery) and also resulting from various chronic pathologies affecting the anterior segment of the eyeball, such as the degenerations of the corneal tissue, which compositions contain one or more miotic agents, such as cholinomimetic active agents and cholinesterase inhibitors, in combination with one or more hypertonic agents, such as sulfacetamide and derivatives thereof, sodium chloride, glucose and glycerol.

L'invention concerne des compositions ophtalmiques capables de réduire les altérations de la fonction visuelle (par exemple la perception de halos, les éblouissements, et la diminution de la vision nocturne et crépusculaire), qui peuvent être causées par des opérations de kératectomie effectuées au laser ou selon des techniques traditionnelles, par des implants intra-oculaires (chirurgie de la cataracte), ou par diverses pathologies chroniques qui touchent le segment antérieur du globe oculaire, par exemple la dégénérescence du tissu cornéen. Ces compositions contiennent un ou plusieurs agents myotiques, comme des agents cholinomimétiques actifs et des inhibiteurs de la cholinestérase, associés à un ou plusieurs agents hypertoniques, par exemple le sulfacétamide et des dérivés de celui-ci, le chlorure de sodium, le glucose, et le glycérol.

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