C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 31/711 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C40B 30/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2663962
The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-15, miR-26, miR-31, miR-145, miR-147, miR-188, miR- 215, miR-216, miR-331, mmu-miR-292-3p, and using nucleic acid comprising all or part of the miR-15, miR-26, miR-31, miR-145, miR-147, miR-188, miR-215, miR-216, miR-331, mmu- miR-292-3p sequences to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
La présente invention concerne des méthodes et des compositions permettant d'identifier des gènes ou des voies génétiques modulés par miR-15, miR-26, miR-31, miR-145, miR-147, miR-188, miR- 215, miR-216, miR-331, mmu-miR-292-3p, et d'utiliser un acide nucléique comprenant tout ou partie des séquences miR-15, miR-26, miR-31, miR-145, miR-147, miR-188, miR-215, miR-216, miR-331, mmu- miR-292-3p pour moduler un gène ou une voie génique, d'utiliser ce propfil dans l'évaluation de l'état d'un patient et/ou le traitement d'un patient avec un ARNmi approprié.
Bader Andreas G.
Brown David
Byrom Mike
Johnson Charles D.
Patrawala Lubna
Asuragen Inc.
Fasken Martineau Dumoulin Llp
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