Mirac proteins

Details Mirac proteins Mirac proteins

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) A61K 38/49 (2006.01) C07K 14/00 (2006.01) C07K 14/575 (2006.01) C12N 9/00 (2006.01) C12N 9/24 (2006.01) C12N 9/48 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2754056

This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.

Cette invention concerne un procédé de production de protéines biologiques conditionnellement actives à partir de protéines sauvages, en particulier des protéines thérapeutiques, qui sont inactivées réversiblement ou irréversiblement dans des conditions physiologiques normales pour le type sauvage. Par exemple, les protéines évoluées sont virtuellement inactives à température corporelle, mais actives à des températures plus basses.

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