C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/16 (2006.01) C12N 9/22 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2256526
An endonuclease isolated from celery, CEL I, is disclosed as well as methods for use in detection of mutations in targeted polynucleotides. The methods facilitate localization and identification of mutations, mismatches and polymorphisms. The enzyme recognizes every type of mismatch regardless of the sequence context in which the mismatch resides and the enzyme is active in pH ranges from acidic to basic.
L'invention porte sur une endonucléase isolée à partir du céleri, la CEL I, et sur ses méthodes d'utilisation pour la détection de mutations dans des polynucléotides ciblés. Ces méthodes facilitent la localisation et l'identification des mutations, des mésappariements et des polymorphismes. L'enzyme reconnaît tous les types de mésappariements quel que soit le contexte des séquences où réside le mésappariement. L'enzyme est active dans une plage de pH allant de l'acide au basique.
Borden Ladner Gervais Llp
Fox Chase Cancer Center
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