Misoprostol

Details Misoprostol Misoprostol

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) C07F 7/22 (2006.01)

Patent

CA 2176763

In a process for making synthetic prostaglandin-type compounds such as misoprostol, organo metallic cuprate complexes capable of reacting with cyclopentenones are prepared by reaction of an alkyl lithium compound with a cuprous halide, followed by reaction of the resulting complex with a vinyl stannane, using an excess of alkyl lithium in the initial reaction and maintaining the excess present during the formation of the organo metallic cuprate complex.

Dans une méthode pour obtenir des composés synthétiques de type prostaglandine, comme le misoprostol, des complexes organiques de cuprate métallique, pouvant réagir avec des cyclopenténones, sont préparés par réaction d'un alkyl-lithium avec un halogénure cuivreux, suivie de la réaction du complexe résultant avec un vinylstannane, en présence d'un excès d'alkyl-lithium dans la réaction initiale et en conservant cet excès lors de la formation du complexe organique de cuprate métallique.

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