Mitigation of cot-1 dna distortion in nucleic acid...

Details Mitigation of cot-1 dna distortion in nucleic acid... Mitigation of cot-1 dna distortion in nucleic acid...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2630416

A novel method of suppressing non-specific cross-hybridization between repetitive elements present in nucleic acid probes and corresponding repetitive elements in the target nucleic acid by using DNA synthesized to contain a plurality of repetitive elements while avoiding low and single copy sequences.

La présente invention concerne un procédé innovant pour la suppression de l'hybridation croisée non spécifique entre les éléments répétitifs présents dans des sondes d'acide nucléique et les éléments répétitifs correspondants dans l'acide nucléique cible à l'aide d'un ADN qui a été synthétisé pour qu'il contienne plusieurs éléments répétitifs tout en évitant les séquences en un seul ou quelques exemplaires.

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