Mitochondria protecting agents for treating mitochondria...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/135 (2006.01) A61K 31/00 (2006.01) A61K 31/04 (2006.01) A61K 31/05 (2006.01) A61K 31/06 (2006.01) A61K 31/085 (2006.01) A61K 31/12 (2006.01) A61K 31/136 (2006.01) A61K 31/155 (2006.01) A61K 31/22 (2006.01) A61K 47/48 (2006.01) C07C 39/08 (2006.01) C07C 39/11 (2006.01) C07C 39/19 (2006.01) C07C 69/017 (2006.01) C07C 215/78 (2006.01) C07C 215/80 (2006.01) C07C 217/84 (2006.01) C07C 279/18 (2006.01) C07D 215/20 (2006.01) C07D 311/72 (2006.01)

Patent

CA 2319131

The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm- blooded animal in need thereof, and composition of this invention contains a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases which may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus, Parkinsons's Disease, neuronal and cardiac ischemia, Huntington's disease and stroke.

La présente invention porte sur des agents protégeant les mitochondries et destinés à traiter des maladies dans lesquelles le dysfonctionnement mitochondrial entraîne une dégénération tissulaire. L'invention porte plus spécifiquement sur des composés, des compositions et des procédés utilisés dans ce traitement. Les procédés de cette invention consistent à administrer à un animal à sang chaud nécessitant ce traitement une quantité pharmaceutiquement efficace d'un agent protégeant les mitochondries. Une composition de cette invention renferme un agent protégeant les mitochondries en combinaison avec un excipient ou diluant pharmaceutiquement acceptable. Les maladies associées aux mitochondries et pouvant être traitées par le procédé de l'invention sont notamment (mais pas exclusivement) la maladie d'Alzheimer, le diabète sucré, la maladie de Parkinson, l'ischémie neuronale et cardiaque, la chorée d'Huntington et l'ictus cérébral.

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