C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/00 (2006.01) A61K 45/00 (2006.01) C07C 50/28 (2006.01) C07C 239/20 (2006.01) C07D 233/84 (2006.01) C07D 311/04 (2006.01) C07D 311/72 (2006.01) C07D 339/06 (2006.01) C07D 339/08 (2006.01)
Patent
CA 2630600
The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.
La présente invention concerne un promédicament antioxydant visant des mitochondries, utile dans la prévention ou le traitement de maladies ou d~états associés à un dysfonctionnement mitochondrial qui résulte de changements dans l'environnement redox mitochondrial. Les promédicaments antioxydants de l'invention sont produits en modifiant un antioxydant pour un acide gras afin que le promédicament résultant vise et soit activé par une enzyme de bêta-oxydation d'acide gras mitochondrial.
Anders Marion W.
Robotham James L.
Sheu Shey-Shing
Borden Ladner Gervais Llp
University Of Rochester
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