G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/569 (2006.01) A61K 31/03 (2006.01) A61K 31/343 (2006.01) A61K 31/352 (2006.01) A61K 31/357 (2006.01) A61K 31/55 (2006.01) G01N 33/574 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2760779
The present invention relates to the compounds useful in the prevention and/or treatment of tumours. More specifically the present invention relates to inhibitors of the activity of the electron transport chains and/or the mitochondrial TCA cycle in glioma-initiating cells (GICs) for use in a method for preventing and/or treating tumours presenting glioma-initiating cells (GICs) in a subject who has undergone a prior removal of a tumour glioma bulk. The present invention further provides a pharmaceutical composition containing the inhibitors of the invention and a screening method for identifying the inhibitors of the invention.
L'invention concerne des composés utiles pour prévenir et/ou pour traiter des tumeurs. En particulier, l'invention concerne des inhibiteurs de l'activité des chaînes de transport d'électrons et/ou du cycle mitochondrial TCA dans des cellules initiatrices de gliome (GIC), à utiliser dans une méthode pour prévenir et/ou pour traiter des tumeurs présentant des cellules initiatrices de gliome (GIC) chez un sujet chez qui on a retiré antérieurement une grosseur de gliome tumoral. L'invention concerne également une composition pharmaceutique contenant des inhibiteurs selon l'invention et une méthode de criblage servant à identifier des inhibiteurs selon l'invention.
Clement Virginie
Radovanovic Ivan
Hopitaux Universitaires de Geneve
Kirby Eades Gale Baker
Universite de Geneve
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