C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 317/48 (2006.01) A61K 31/135 (2006.01) A61K 31/145 (2006.01) A61K 31/167 (2006.01) A61K 31/343 (2006.01) A61K 31/357 (2006.01) A61K 31/36 (2006.01) A61K 31/381 (2006.01) A61K 31/443 (2006.01) A61K 31/4439 (2006.01) A61P 9/10 (2006.01) C07C 225/06 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01) C12Q 1/32 (2006.01) C12N 9/02 (2006.01)
Patent
CA 2679882
The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
L'invention concerne des composés qui fonctionnent comme modulateurs d'activité d'aldéhyde déshydrogénase-2 mitochondrial (ALDH2); et des compositions pharmaceutiques comprenant les composés. La présente invention concerne des procédés thérapeutiques impliquant l'administration d'un composé de l'invention, ou d'une composition pharmaceutique de l'invention. La présente invention concerne en outre des dosages permettant d'identifier des agonistes d'ALDH2.
Chen Che-Hong
Mochly-Rosen Daria
Fetherstonhaugh & Co.
The Board Of Trustees Of The Leland Stanford Junior University
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