Mitochondrial dna damage as a predictor of coronary...

Details Mitochondrial dna damage as a predictor of coronary... Mitochondrial dna damage as a predictor of coronary...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2360597

The present invention demonstrates that mitochondrial DNA damage occurs prior to, or simultaneous with, atherosclerotic lesion development, that aortic mitochondrial DNA damage increases with age, and that genotype and diet both influence the level of mitochondrial DNA damage. Hence, the present invention demonstrates that mitochondrial DNA damage occurs early in atherosclerosis, and may be an initiating event in atherogenesis, and provides methods to predict coronary atherosclerotic heart disease based upon the amount of mitochondrial DNA damage.

L'invention concerne le fait qu'une lésion d'ADN mitochondrial se produit avant, ou simultanément au développement d'une lésion athéroscléreuse, que les lésions d'ADN mitochondrial aortique augmentent avec l'âge, et que le génotype et le régime alimentaire influencent le taux de lésions d'ADN mitochondrial. Par conséquent, l'invention a trait au fait qu'une lésion d'ADN mitochondrial se produit à un stade précoce de l'athérosclérose et peut constituer un événement déclencheur de l'athérogenèse, ainsi qu'à des méthodes de prédiction d'affection cardio-vasculaire athéroscléreuse coronaire basées sur la quantité de lésions d'ADN mitochondrial.

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