C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2704361
The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying a mtDNA mutation in the sample and comparing the level of the mtDNA mutation present in the sample with a reference value The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes Further, said methods may be also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
La présente invention concerne des procédés pour prédire, diagnostiquer et surveiller un cancer. Les procédés comportent l'obtention d'échantillons biologiques, l'extraction d'ADN mitochondrial (ADNmt) des échantillons, la quantification d'une mutation d'ADN mitochondrial dans l'échantillon et la comparaison du niveau de mutation d'ADNmt avec une valeur de référence. Les procédés de l'invention peuvent également être efficaces dans le criblage de nouveaux agents thérapeutiques et de régimes de traitement, et peuvent aussi s'utiliser pour surveiller la réponse d'un sujet à un traitement préventif ou thérapeutique.
Alexander Jude
Creed Jennifer
Dakubo Gabriel
Harbottle Andrew
Maggrah Andrea
Blake Cassels & Graydon Llp
Genesis Genomics Inc.
Mitomics Inc.
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