Mitochondrial dosimeter

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2403222

Mitochondrial mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition.

Les mutations mitochondriales se produisent suite au contact d'une personne avec un polluant du milieu. Les mutations mitochondriales sont facilement détectables dans des fluides corporels. La mesure des mutations mitochondriales dans des fluides corporels peut être utilisée en tant que dosimètre pour surveiller l'exposition au polluant du milieu. Des mutations mitochondriales peuvent également être détectées chez des patients atteints d'un cancer. Des sondes et des amorces contenant des séquences de mitochondries mutantes peuvent être utilisées pour surveiller l'état d'un patient.

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