C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07K 14/47 (2006.01) C12N 15/87 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2353777
The present application relates to a mitochondrial deoxynucleotide carrier (DNC) which transports deoxynucleoside diphosphates, wherein. said carrier: a) catalyses the exchange of dATP for dADP or ADP with first-order kinetics and a rate constant of 0.02min -01; b) has a pH optimum at pH6.8; and c) exchanges dATP more efficiently from dNDPs than for NTPs, dNTP, dNMPs and pyrophosphate, as well as to the use of such a carrier in the design of nucleoside analogue drugs.
Dolce Vincenza
Fiermonte Giuseppe
Palmieri Ferdinando
Runswick Michael
Walker John
Mbm Intellectual Property Law Llp
Medical Research Council
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