Mitochondrially delivered anti-cancer compounds

Details Mitochondrially delivered anti-cancer compounds Mitochondrially delivered anti-cancer compounds

C - Chemistry, Metallurgy

07

F

C07F 9/54 (2006.01) A61K 31/355 (2006.01) A61K 33/42 (2006.01) A61P 35/00 (2006.01) C07D 311/72 (2006.01)

Patent

CA 2734208

This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In one aspect the invention concerns mitochondrially delivered pro-oxidant anti-cancer compounds that generate reactive oxygen species and induce apoptosis of cancerous cells. The delivery moiety can be a lipophilic cation and the pro-oxidant moiety can be a pro-oxidant vitamin E analogue, such as .alpha.-tocopheryl succinate, .alpha.-tocopheryl maleate, .alpha.-tocopheryl maleyl amide, or 2,5,7,8-tetramethyl-2R- (4R,8R,12-trimethyltridecyl)-chroman-6-yloxyacetic acid (.alpha.- tocopheryloxyacetic acid).

La présente invention concerne des composés anticancéreux et des procédés de traitement et de prévention du cancer. Selon un aspect de linvention, linvention concerne des composés anticancéreux pro-oxydants distribués de manière mitochondriale qui génèrent des espèces doxygène réactives et qui induisent l'apoptose des cellules cancéreuses. La fraction de distribution peut être un cation lipophile et la fraction de pro-oxydant peut être un analogue de vitamine E pro-oxydant, comme du succinate dalpha-tocophérol, du maléate dalpha-tocophérol, de lamide maléique dalpha-tocophérol, ou de lacide oxyacétique 2,5,7,8-tétraméthyl-2R-(4R,8R,12-triméthyltridécyl-chroman-6 (acide oxyacétique dalpha-tocophérol).

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