C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/655 (2006.01) A61K 47/24 (2006.01) A61K 47/48 (2006.01) A61P 39/06 (2006.01) C07F 9/54 (2006.01)
Patent
CA 2311318
The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3)+XR.Z- where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.
L'invention concerne des composés antioxydants ciblés vers les mitochondries. Un composé de l'invention comporte un cation lipophile couplé de façon covalente à une fraction antioxydante. Dans des modes de réalisation préférés, le cation lipophile est le cation triphénylphosphonium, et le composé est représenté par la formule P(Ph3)<+>XR.Z<->, dans laquelle X est un groupe de liaison, Z est un anion et R est une fraction antioxydante. L'invention concerne également des compositions pharmaceutiques contenant les composés antioxydants ciblés vers les mitochondries, et des procédés thérapeutiques ou prophylactiques destinés à des patients qui pourraient bénéficier d'un stress oxydatif réduit, ces procédés comportant l'étape consistant à administrer les composés de l'invention.
Murphy Michael Patrick
Smith Robin A. J.
Antipodean Pharmaceuticals Inc.
Sim & Mcburney
University Of Otago
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