Mitochondrially targeted antioxidants in the treatment of...

A - Human Necessities – 61 – K

Patent

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A61K 47/48 (2006.01) A61P 5/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2573456

The present invention relates to the use of a mitochondrially targeted antioxidant, e.g. de~rivatives of vitamin E, coenzyme Q10 or a glutathione peroxidase mimetic, in the treatment and prevention of liver diseases and/or epithelial cancers. The present invention also relates to pharmaceutical compositions containing the antioxi~dant(s) intended for such use. Furthermore the invention relates to the manufacture of me~dicaments containing the antioxidant(s) useful for such prevention and treatment.

L'invention concerne l'utilisation d'un antioxydant ciblé de manière mitochondriale, par exemple, des dérivés de vitamine E, de coenzyme Q10 ou un mimétique de la glutathione peroxydase, pour traiter ou prévenir les maladies hépatiques et/ou les cancers epithéliaux. L'invention concerne également des compositions pharmaceutiques contenant les ou les antioxydant(s) destiné(s) à cette utilisation. L'invention concerne enfin la production de médicaments contenant ledit/lesdits antioxydant(s) utilisé(s) pour ladite prévention et ledit traitement.

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