C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/06 (2006.01) C07D 401/04 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2509565
Compounds are described which inhibit mitogen activated protein kinase- activated protein kinase-2 (MK-2). Methods of using such compounds for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNF.alpha., are described, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Therapeutic compositions, pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.
Cette invention concerne des composés qui inhibent la protéine kinase-2 activée par la protéine kinase activée par des agents mitogènes (MK-2). Cette invention concerne également des procédés d'utilisation de ces composés pour l'inhibition de la MK-2 ainsi que pour la prévention ou le traitement d'une maladie ou d'un trouble induit par le TNF.alpha., lequel procédé consiste à administrer au sujet un composé inhibant la MK-2 de la présente invention. Cette invention concerne enfin des compositions thérapeutiques, des compositions pharmaceutiques ainsi que des nécessaires renfermant les composés inhibant la MK-2 de cette invention.
Anderson David R.
Buchler Ingrid P.
Hegde Shridhar G.
Mahoney Matthew W.
Meyers Marvin J.
Anderson David R.
Buchler Ingrid P.
Hegde Shridhar G.
Mahoney Matthew W.
Meyers Marvin J.
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