Mitogen activated protein kinase-activated protein kinase-2...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 471/06 (2006.01) C07D 401/04 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2509565

Compounds are described which inhibit mitogen activated protein kinase- activated protein kinase-2 (MK-2). Methods of using such compounds for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNF.alpha., are described, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Therapeutic compositions, pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.

Cette invention concerne des composés qui inhibent la protéine kinase-2 activée par la protéine kinase activée par des agents mitogènes (MK-2). Cette invention concerne également des procédés d'utilisation de ces composés pour l'inhibition de la MK-2 ainsi que pour la prévention ou le traitement d'une maladie ou d'un trouble induit par le TNF.alpha., lequel procédé consiste à administrer au sujet un composé inhibant la MK-2 de la présente invention. Cette invention concerne enfin des compositions thérapeutiques, des compositions pharmaceutiques ainsi que des nécessaires renfermant les composés inhibant la MK-2 de cette invention.

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