C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A01N 43/78 (2006.01) A01N 51/00 (2006.01) A61K 31/425 (2006.01) C07K 14/705 (2006.01) C07K 17/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2508346
The invention relates generally to a family of polypeptides from mitochondrial membranes, which bind insulin sensitizing, antidiabetic thiazolodinediones, and nucleic acid sequences encoding the family of polypeptides. The invention relates to methods of identifying therapeutic agents that bind to the polypeptides of the present invention. The invention further relates to methods useful for treating or modulating metabolic disorders in mammals in need of such biological effect.
L'invention concerne généralement une famille de polypeptides provenant de membranes mitochondriales qui se lient aux thiazolodinédiones antidiabétiques à sensibilité insulinique et à des séquences d'acides nucléotiques codant la famille des polypeptides. Cette invention a aussi pour objet des méthodes d'identification d'agents thérapeutiques qui se lient aux polypeptides susmentionnés, ainsi que des méthodes utilisées dans le traitement ou la modulation de troubles métaboliques chez les mammifères nécessitant un tel effet biologique.
Colca Jerry R.
Mcdonald William G.
Pharmacia Corporation
Sim & Mcburney
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