C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/54 (2006.01) A61K 33/42 (2006.01)
Patent
CA 2536546
This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds.The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.
L'invention concerne des composés antioxydants amphiphiles pharmaceutiquement acceptables, des compositions et des formes posologiques comprenant lesdits composés, des procédés et des utilisations desdits composés. Les composés de l'invention sont tous des dérivés de la mitoquinone, ces derniers étant des dérivés de méthoxyphényle alkyle triphénylphosphonium ou de méthoxy dioxocyclohexadiène alkyle triphénylphosphonium. Les composés, les compositions et les formes posologiques, les utilisations et les procédés sont utilisés, par exemple, dans le traitement de maladies ou d'états pathologiques associés au stress oxydatif.
Smith Robin
Taylor Kenneth Martin
Antipodean Pharmaceuticals Inc.
Bennett Jones Llp
LandOfFree
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