Mitotic kinesin inhibitor

Details Mitotic kinesin inhibitor Mitotic kinesin inhibitor

C - Chemistry, Metallurgy

07

D

C07D 285/12 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 37/02 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2522594

An M-stage kinesin Eg5 inhibitor which contains as an active ingredient either a thiadiazoline derivative represented by the general formula (I): [wherein R1 represents hydrogen, etc.; R2 represents hydrogen, -C(=W)R6 (wherein W represents oxygen or sulfur and R6 represents (un)substituted lower alkyl, etc.), etc.; R3 represents -C(=Z)R19 (wherein Z represents oxygen or sulfur and R19 represents (un)substituted lower alkyl, etc.) etc.; R4 represents (un)substituted lower alkyl, etc.; and R5 represents (un)substituted aryl, etc.] or a pharmacologically acceptable salt of the derivative.

L'invention concerne un inhibiteur de kinésine Eg5 de stade M qui contient en tant qu'ingrédient actif soit un dérivé de thiadiazoline de formule générale (I) [dans laquelle R?1¿ représente hydrogène, etc.; R?2¿ représente hydrogène, -C (=W) R?6¿ (W représentant oxygène ou soufre et R?6¿ représentant alkyle inférieur substitué ou non, etc.), etc.; R?3¿ représente -C (=Z) R?19¿ (Z représentant oxygène ou soufre et R?19¿ représentant alkyle inférieur substitué ou non, etc.), etc.; R?4¿ représente alkyle inférieur substitué ou non, etc.; et R?5¿ représente aryle substitué ou non, etc.], soit un sel acceptable sur le plan pharmacologique dudit dérivé.

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