Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

A - Human Necessities

61

K

A61K 31/505 (2006.01) C07D 239/91 (2006.01)

Patent

CA 2549641

The present invention relates to 2,3-diarylquinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

L'invention porte sur des composés de 2,3-diarylquinazolinone s'avérant utiles pour traiter les maladies à prolifération cellulaire et les troubles associés à l'activité de la kinésine KSP, et inhiber la kinésine KSP. L'invention porte également sur des compositions comprenant lesdits composés, et sur des méthodes de traitement des cancers chez les mammifères les utilisant.

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