C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/36 (2006.01) A61K 31/513 (2006.01)
Patent
CA 2547209
The present invention relates to 2-phenylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention concerne des composés de 2-phénylpyrimidinone qui sont utiles pour traiter des maladies à prolifération cellulaire, des troubles associés à l'activité de la kinésine KSP, et pour inhiber la kinésine KSP. Cette invention concerne des compositions comprenant ces composés, et des méthodes permettant d'utiliser ces compositions pour traiter un cancer chez des mammifères.
Arrington Kenneth L.
Fraley Mark E.
Hartman George D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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