Mitotic kinesin inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 231/06 (2006.01) A61K 31/415 (2006.01) C07D 231/10 (2006.01)

Patent

CA 2589827

The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des composés de dihydropyrazole utilisés dans le traitement de maladies prolifératives cellulaires, de troubles associés à l'activité de la kinésine de la protéine KSP et dans l'inhibition de la kinésine de la protéine KSP. Cette invention a aussi pour objet des compositions qui renferment ces composés et leurs méthodes d'utilisation dans le traitement de cancer chez des mammaliens.

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