C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/00 (2006.01)
Patent
CA 2560213
The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention concerne des dérivés d'aniline benzylique N-substituée qui sont utiles pour traiter des maladies cellulaires prolifératives, pour traiter des troubles associés à l'activité de kinésine KSP et pour inhiber la kinésine KSP. L'invention concerne aussi des compositions qui comprennent ces composés et des procédés d'utilisation pour traiter le cancer chez les mammifères.
Garbaccio Robert M.
Olson Christy M.
Tasber Edward S.
Torrent Maricel
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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