C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 7/10 (2006.01) A61K 31/695 (2006.01) A61K 31/415 (2006.01) C07D 231/06 (2006.01)
Patent
CA 2599436
The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention concerne des composés de dihydropyrazole utilisés dans le traitement des maladies cellulaires prolifératives, dans le traitement des troubles associés à l'activité de la kinésine KSP, et dans l'inhibition de la kinésine KSP. L'invention concerne également des compositions contenant ces composés, et des méthodes d'utilisation de celles-ci dans le traitement du cancer chez les mammifères.
Coleman Paul J.
Cox Christopher D.
Hartman George D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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