Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2547746

The present invention relates to 2-phenylthienylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

L'invention concerne des composés de 2-phénylthienylpyrimidinone utiles dans le traitement de maladies cellulaires prolifératives, aux fins de traitement de troubles associés à l'activité de la kinésine KSP et aux fins d'inhibition de celle-ci. L'invention concerne également des compositions comprenant ces composés et des procédés d'utilisation de celles-ci dans le traitement du cancer chez des mammifères.

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