C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/513 (2006.01) A61P 35/00 (2006.01) C07D 333/36 (2006.01) C07D 333/38 (2006.01)
Patent
CA 2595127
The present invention relates to fluorinated 2-aminomethylthienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention concerne des composés de 2-aminométhylthiénopyrimidinone fluorés qui sont utilisés, d'une part, pour traiter des maladies prolifératives cellulaires, des troubles liés à une activité de la kinésine KSP et, d'autre part, pour inhiber la kinésine KSP. Cette invention a aussi pour objet des compositions qui renferment ces composés et leurs méthodes d'utilisation dans le traitement du cancer chez les mammaliens.
Coleman Paul J.
Hartman George D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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